大骨节病(Kaschin-Beck Disease)是一种慢性关节畸形病,主要表现为骨关节及其他组织营养不良性退行性病变。本病流行于我国低硒地带中的低硒环境,人体处于贫硒营养状态时,机体含硒酶一谷胱甘肽过氧化物酶(GSH-px)活性显著降低;临床实践证明亚硒酸钠和亚硒酸钠伍用维生素E对本病疗效极为显著。因此,作者认为大骨节病是低硒环境所产生的生物效应,而在正常硒环境并无本病流行。

The Kaschin-Beck disease occurs generally in the low selenium environment of China's low selenium areas, and nondisease region is generally distributed in the normal selenium environment. In both environments, the selenium dynamics in the course of fetal growth, is about the same. There is a decreased tendency of selenium content in fetus of five months. The selenium content increases when the fetus is six months. After that it decreases again. It is the lowest with in a month before birth and increases after birth. But in both environments, the changes of selenium content in the fetus are based on the different selenium levels.