• 环境与健康地理 •

### 中国手足口病时空分异特征及影响因素

1. 1.东北师范大学地理科学学院,长春 130024
2.长白山地理过程与生态安全教育部重点实验室,长春 130024
• 收稿日期:2021-09-03 修回日期:2022-01-10 出版日期:2022-03-25 发布日期:2022-05-25
• 作者简介:宋飏(1978-), 女, 吉林长春人, 博士, 高级工程师, 研究方向为城市地理与城乡规划、环境健康地理。E-mail: song0317@nenu.edu.cn
• 基金资助:
国家自然科学基金项目(41630749);国家自然科学基金项目(4217010553);国家社会科学基金项目(17BJL051);中央高校基本科研业务费专项资金团队项目(1709103);中央高校基本科研业务费专项资金团队项目(2412020FZ001)

### Spatio-temporal differentiation characteristics and influencing factors of hand, foot, and mouth disease in China

SONG Yang1,2(), LIU Yanxiao1, ZHANG Yu1, WANG Shijun1,2

1. 1. School of Geographical Science, Northeast Normal University, Changchun 130024, China
2. Key Laboratory of Geographical Processes and Ecological Security of Changbai Mountains, Ministry of Education, Changchun 130024, China
• Received:2021-09-03 Revised:2022-01-10 Published:2022-03-25 Online:2022-05-25
• Supported by:
National Natural Science Foundation of China(41630749);National Natural Science Foundation of China(4217010553);Program of the National Social Science Fund of China(17BJL051);Fundamental Research Funds for the Central Universites(1709103);Fundamental Research Funds for the Central Universites(2412020FZ001)

Abstract:

The Healthy China initiative is one of the important strategies in the new period of China. Hand, foot, and mouth disease (HFMD) is a global health threaten. It is a typical infectious disease with a wide and universal impact in China, especially to infants. This paper develops a theoretical framework for the study of infectious diseases from the health geography perspective. The framework used concentration and spatial analysis methods to analyze the spatio-temporal differentiation and evolution patterns of HFMD incidence in China from 2008 to 2017. Using spatial correlation analysis and geographic detection of 18 risk factors for the incidence of HFMD, we identified the main influencing factors and revealed the mechanism of the geographic distribution of HFMD. The results show that: (1) the theoretical framework of infectious disease research from the perspective of health geography includes three subsystems: the basic link of infectious disease, influencing factors, and the distribution and diffusion state of the infectious disease with mutual interaction and impact between and within the three subsystems. (2) From 2008 to 2017, the incidence rate of HFMD in China showed a fluctuating increase, with a two-year cycle. In addition, the incidence in the even years was higher than that in the odd years. The peaks of incidence are observed in late spring, early summer, late autumn, and early winter. (3) The incidence rate of HFMD from 2008 to 2010 did not reflect obvious characteristics of the spatial agglomeration. However, the incidence rate had a strong spatial autocorrelation from 2011 to 2017. Hotspots were mainly distributed in southern humid areas such as Guangdong, Guangxi, and Hainan. Moreover, the spots were evolving from north to south, and changing from small and scattered to large and concentrated spots. HFMD mainly occurred in three typical areas, namely, areas with hot and humid climates, economically underdeveloped areas with poor medical resources, and densely populated areas prone to clustered infections. (4) Twelve factors have passed the test of significance of correlation analysis and geographical detection. The explanatory power of the factors that positively affect the incidence rate are sorted as follows: AT > AP > RH > BP > PD > RND > PCG; factors that have negative correlation are sorted as follows: SD > WS > AQI > DEM > HBP. The interaction between AT and AP and other factors is the most obvious. This study provides an empirical basis for research into HFMD's health geography, pathology, and epidemiology, and important scientific support and policy reference for serving the strategy of Healthy China and epidemic control and prevention.