The earth surface oxygen concentration on the Qinghai-Tibet Plateau is the result of the combined effect of multi-factors, such as elevation, topography, climate, water, vegetation, and soil, among them, the relative contributions of altitude, temperature, vegetation coverage and leaf area index are -39.58%, 35.50%, and 24.92%, respectively. The earth surface oxygen concentration on the plateau primarily shows the difference from southeast to northwest, which is mainly related to the effect of vegetation on oxygen production depending on precipitation; secondly shows the difference on east-west extension and north-south turnover, which is mainly related to the effect of atmospheric pressure on relative oxygen concentration depending on temperature and terrain; thirdly shows the vertical zonation, which is mainly related to the effect of atmospheric pressure on the relative oxygen concentration depending on the terrain and temperature, bond with the effect of vegetation on oxygen production depending on temperature and precipitation. The earth surface oxygen concentration can quantitatively reveal the spatio-temporal pattern of the physiographical characteristics of the earth surface. Accordingly, we divide the natural zone of the Qinghai-Tibet Plateau into 3 first-grade regions and 17 second-grade zones. In the southeastern subtropical forest-forest steppe region, including 2 second-grade zones, the annual average oxygen concentration is 20.35%, the average oxygen concentration in July is 20.45%, and the average oxygen concentration in January is 20.27%. In the eastern temperate forest-steppe region, including 5 second-grade zones, the annual average oxygen concentration is 20.10%, the average oxygen concentration in July is 20.23%, and the average oxygen concentration in January is 20.00%. In the western cold temperate grassland-desert-steppe region, including 10 second-grade zones, the annual average oxygen concentration is 20.00%, the average oxygen concentration in July is 20.10%, and the average oxygen concentration in January is 19.91%.