With remote sensing data and GIS, the classification system of wetland landscape of the region along the Yellow River in Henan Province is established. Using the indexes of the landscape pattern, such as landscape diversity index, landscape dominance index, landscape fragmentation index, distribution centroid and extended dimension, this article presents the dynamic change of wetland landscape pattern from 1987 to 2002. The results showed that: (1) The total area, the patch number and other index of wetland reduced obviously. The total area of wetland reduced 19.18%. The number of patches increased 21.17%, the patch density increased 50%, and the total perimeter length increased 1,290,491 m from 1987 to 2002. (2) Disturbed by human activity, landscape diversity index decreased from 1.1740 in 1987 to 0.9803 in 2002. While landscape dominance index increased from 0.4355 in 1987 to 0.6291 in 2002, and landscape fragmentation index increased from 0.0141 to 0.0172, which means that the shape of wetland was much irregular. (3) During the last nearly 20 years, the total area of the rice wetland increased, while the area of other types decreased. Among these wetland types, the area of the marsh wetland decreased most obviously. In 1987, it occupied 0.5% of the total area, but in 2002, it only occupied 0.11%.