Tourism destination is the core concept of tourism geography. With deepening development of globalization, informatization, and network interaction, profound change has occurred in the spatial form, scale, and relationship of tourism destinations. Route tourism destinations have become an important product of modern tourism and a new spatial form of tourism consumption. Therefore, based on the relationalism perspective of post-structuralism, this study developed a conceptual framework and research system of route tourism destinations, and is intended to provide theoretical support and practical reference for related research. It is believed that the spatial organization and the spatial scale of tourism resource elements have undergone profound changes, and that the characteristics of the era of mobility require us to dismiss the traditional static and structured destination cognition system, and reconsider tourism resources under the background of modernization. The new cognitive system and multiscale analysis framework will improve on the existing cognitive structure of the tourist destination. Route tourism reflects a community organization and spatial continuum of relevance, fluidity, and dynamics formed by interaction in a specific direction with certain themes of nature, culture, and transportation as the relevant axes. Moreover, route tourism is the result of the linkage and spatial association of various tourism elements such as resources, services, infrastructure, and stakeholders. The theoretical perspective of post-structuralism provides a basis for the study of route tourism destinations, and relational linkage and relational space have robust theoretical applicability in the development and evolution of the organizational structure and spatial structure of route tourism destinations. The evolution of the process, mechanism, and multiscale research of route tourism from the perspective of post-structuralism theory provides a reference plan for further theoretical and practical development, and for expansion of new perspectives and new fields of tourism destination research.

Economic globalization has reshaped the world economy's spatial pattern while simultaneously changing the context for developing economic geography theories. This study revisited the changing features of economic globalization and investigated its geographical implications. Next, it summarized the new trends in economic geography studies in response to the changing economic globalization. Lastly, this study proposed a research agenda for domestic economic geography studies by combining the requirements of global trends and national strategies. The main findings include the following: The scale of geographical integration during economic globalization keeps shrinking, leading to a pattern of regionalization. The driving forces of economic globalization have gradually shifted from cost-saving to innovation. Accordingly, the benefits of economic globalization will be reallocated between developed and developing countries. The trade-offs between efficiency and resilience alter the global value chain, shifting outsourcing from off-shoring to re-shoring or near-shoring. The changing economic globalization has witnessed the rising effects of geographical distances, institutions, and resilience on increasing the inequality of the global economic geography. In economic geography, the scalar structures shifted from the global-local to the global-national-local. The relational networks evolved toward a multi-level, multi-agent, and multi-scale one. The role of the nation has been revisited. More attention has been paid to geopolitical hotspots. Overall, economic geography's institutional, cultural, relational, and evolutionary turns exhibit an emerging trend to convergence. In such a setting, domestic economic geography should find a new balance between global trends and national strategies. This study proposed seven research issues, including: (1) the practice of the Belt and Road and the pattern of inclusive globalization; (2) the economic geography of dual circulation; (3) the paths and resilience of regional development in response to the global production network restructuring; (4) the evolution and competitiveness of industrial clusters; (5) the building of multi-level innovation systems; (6) the regional sustainable development within the global environmental governance system; and (7) the impact of geo-economics on national economic security and interests.