Comprehensive analysis on the present status of pollution of air, water body, soil and its variational regulation in different physicogeographical condition as climate, geology, topography and vegetation, and unven of economic development in China, shows that there, are significant difference in transportation, accumulation and degradation of pollutants, among different geo-graphic regions. Further more different environmental capacity as well as the environmental load and the ability to remove pollutants from the environment are found in different regions. Consequently, policy for control of environmental pollution, should be determined based upon the regulation of physical and economic variation. So the environmental self-purification function could be used effectively by overall planning and rational allocation of industrial-ag-ricultural production, and reducing discharge of pollutants as much as possible by reforming production process and adopt advanced techniques. Simultaneously, environmental management could be strengthening by administrative means, economic measures and the legal system.