Kaschin-Beck’s disease is a non-communicable endemic and distributes widely inchina. This study indicates that the chemical geography in the disease-occurring re-gions is characterized by lower content of sulfur and selenium and high content ofstrontium in drinking water, soil and grain as compared with healthy regions. Thegeographical epidemicity of this disease may be controlled by high content of sulfur andselenium in environment. This disease can also be prevented and cured to a certain extentby chemical compounds containing sulfur. As the cause of this disease has not yet beenwell known, the relationship between this disease and some trace elements, which relatesto sulfur in the field of biogeochemistry, should be further studied.