Spatial organization of economic activities is of great importance for urban studies and urban planning such as urban morphology and relevant urban developmental policies. Traditional studies however overlook the spatial dependency of economic activities, which leads to our knowledge constrained to the geographical or industrial concentration of a region less considering the inner structure of urban spatial economics. The aim of this paper is to explore the inner structure of urban economic activities for Beijing in the period of 1949-2004. With the indicator of gross employment increasing, the urban spatial-economic organization was investigated by means of exploratory spatial data analysis. Specifically, Local Moran's I was used to examine the increase of gross employment for local spatial associations on a postcode level with Rook Spatial Weights and different distance spatial weights. The result indicated, as the foundation for Beijing spatial-economics, there were no significant economic agglomeration areas in the urban center during 1949-1956. However, in the later 50 years, Beijing was gradually forming a mono-centric spatial organization with a huge nuclear anchored in the urban center. At the same time, some towns in the peri-urban area were developed as islands with less spatial-economic relations with their hinterlands. Instead, they kept a close economic linkage with the urban center or other regions. On the city level, the distance for spatial interactions of economic elements was within 60 km in the planned area to form hinterlands, and expanded to 75 km in 1983-2002 when market economy is oriented. After the revival period in 1949-1956, the evolution of Beijing spatial-economic organization experienced six stages: (1) 1957-1982, the urban center was rapidly developed; (2) 1983-1987, Beijing-Tianjin-Langfang became a major economic corridor; (3) 1988-1992, the north of the urban center was rapidly developed; (4) 1993-1997, the urban area spatially expanded; (5) 1998-2002, the urban center was infilled; (6) 2002-2004, perhaps decentralization took on ensuing with spatial restructuring.