Having arisen as a national strategy and institution, the Major Function Zones Planning (MFZP) will play an active role in guiding and restraining China's long-term spatial development pattern. From the perspective of region uniqueness, it is critical to reveal the genesis (formation and evolution) and feedback (identification and planning) principles for MFZP. This paper takes Chongqing Municipality, a typical provincial unit in Southwest China, as an example to identify the suitable spatial pattern for MFZP by Territorial Space Development Conditions Comprehensive Evaluation (TSDCCE). Depending on perceptual observation of suitable pattern, this paper makes a dominant factors restriction hypothesis, defines the topography and urban location as the dominant factors, and then validates the correlation between dominant factors and Major Function-Oriented Zoning (MFOZ) index system. Then, based on the above analysis results, it discusses the restrictive and spatial stability mechanism originated from dominant factors for MFOZ. The results show that: (1) The spatial pattern of suitability is clear in terms of development or protection. The areas suitable for urbanization are mainly metropolitan regions and some surrounding counties, and sub-regional centers (Wanzhou and Qianjiang) also have relatively high suitability. The areas suitable for ecological protection are mainly located in the northeast and southeast of Chongqing, including Daba mountain area, Three Gorges Reservoir area and Wuling mountain area. (2) Topography and urban location factors dominate the MFOZ spatial pattern in this region. Regression analysis showed that more than 70% of the correlation between the MFOZ index and the topographic factor reached a significant level, while the correlation between the MFOZ index and urban location factor is over 40%. The significant levels (R2) of correlation between the weighting index (topography and urban location) and MFOZ flag variables (A and B index) are more than 0.8; The geographic detector finds that the topography's restriction on MFOZ indicators and urban location factors on that are 9 and 7, respectively, which reaches 0.05 significant level and the explanatory degrees for indicators A and B are about 70% and 60%, respectively. Then combining topography factor and urban location factor, it finds that restriction is obvious and the explanatory degrees for A and B are up to about 90%. (3) The spatial stability mechanism is shown in two aspects: one is the stability transfer mechanism based on the dominant factor's restriction, which is called objective stability; the other is the local relativity index system and the internal cancellation mechanism of the algorithm, namely, subjective stability. The coordination of the two mechanisms verifies the regional adaptability and correctness of the zoning technology system.