Regions continue to be one of the most logical and satisfactory ways of organizing the geographical information. Southwest China has always been concerned by geographers at home and abroad for its unique geographical phenomena. Its research vein could be looked into and given some useful suggestions for the future research through analyses of the articles published in Acta Geographica Sinica during 1934-2018. The results show that: (1) Articles about Southwest China covered almost all the subjects of geography, and the research results about geomorphology, meteorological climate, integrated physical geography, and ecological environment are the most widely published, while those on cities, ethnic groups, transportation and health are less concerned; (2) Up to 2018, the research had experienced four stages, early traditional regional research, task-led discipline, connecting the preceding and the following, and diversified development; (3) The periodical changes of the quantity and contents of these articles are influenced by the pattern of national affairs, and by the changes of the research paradigm of geography; (4) The articles published in Acta Geographica Sinica are of high research level, no matter from the academic perspective or the research methods, and many studies on regional nature, humanities, social economy and ecological environment are at the forefront of academic research, representing the academic research on geography of Southwest China; (5) However, the growth rate of articles about this region is far behind the increase in the number of articles in Acta Geographica Sinica, and the external research institutions and universities account for a large proportion of the number of articles, while the locals are weak. Compared with physical geography, there are fewer studies on human geography. As China's "island in the sky" and "cradle of ancient humans beings", Southwest China should be re-examined in the fields of the traditional and modern collision, boundary contact and conflict, and inter-regional contact and competition from the perspective of new regional geography, and continue to achieve the geographical significance of the study region.